Abstract
BACKGROUND: Stroke is a leading cause of death and disability worldwide, and there is still a lack of specific and sensitive biomarkers for its diagnosis. OBJECTIVE: This study aimed to investigate the diagnostic value of FOXO4 and Ep300 proteins in acute ischemic stroke patients who visited the emergency department. METHODS: Patients were consecutively included in the study. The amount of Ep300 and FOXO4 proteins was determined using an enzyme-linked immunosorbent assay (ELISA). Receiver operator characteristic (ROC) analyses of FOXO4 and Ep300 proteins were performed. RESULTS: The study was conducted on a total of 39 acute ischemic stroke patients, 17 females and 22 males, with a mean age of 66.9 ± 11 years. Seventeen females and 23 male control were also included. The discriminative ability of Ep300 protein was not statistically significant (p value = 0.380). FOXO4 protein had moderate discriminative ability (AUC value = 0.705 and p value = 0.002). When the cut-off value for FOXO4 protein was accepted as > 1.15, the sensitivity was 74.29%, the specificity was 64.52%, the positive predictive value was 70.3%, the negative predictive value was 69%, the positive likelihood ratio was 2.09, and the negative likelihood ratio was 0.4. CONCLUSIONS: The study's findings suggest that FOXO4 protein could potentially serve as a valuable biomarker in the diagnosis of stroke in acute ischemic stroke patients.