Abstract
Brain imaging studies of tinnitus patients have revealed marked changes in brain structure and function, but there are inconsistencies in those findings. In this meta-analysis, we investigated concurrence across studies to clarify those abnormalities in brain structure and function in tinnitus. Neuroimaging studies published up to December 6, 2019 were searched in the PubMed, Web of Science, EMBASE, and Cochrane Library databases, Chinese Nation Knowledge Infrastructure, Chinese Biomedical Literature Database, the Chongqing VIP, and Wanfang Database. Study selection, quality assessment, and data extraction were performed by two independent researchers. Anisotropic effect size signed differential mapping (AES-SDM) was used to perform a multimodal analysis of available studies reporting whole-brain structural or functional data in tinnitus patients. There were 14 studies that met the inclusion criteria. The structural dataset comprised 242 tinnitus patients and 217 matched healthy subjects (HS), while the functional dataset included 130 tinnitus patients and 140 matched HS. Our analysis revealed structural alterations in the superior temporal gyrus, middle temporal gyrus (MTG), angular gyrus, caudate nucleus, superior frontal gyrus, and supplementary motor area, as well as functional differences in the MTG, middle occipital gyrus, precuneus, and right inferior parietal (excluding supramarginal and angular) gyri. The multimodal analysis revealed significant differences in the right MTG of tinnitus patients relative to HS. These findings suggest the involvement of the cortico-striatal circuits in the neuropathology of tinnitus.