Long Noncoding RNA UCA1 Is Related to Autophagy and Apoptosis in Endometrial Stromal Cells

长链非编码RNA UCA1与子宫内膜基质细胞自噬和凋亡相关

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作者:Lili Jiang, Yahui Wan, Ziyi Feng, Da Liu, Ling Ouyang, Yan Li, Kuiran Liu

Conclusion

UCA1 is highly expressed in EMS and promotes the proliferation of ESCs but suppresses autophagy and apoptosis. In EMS, UCA1 may be a prognostic marker and therapeutic target.

Results

qRT-PCR analysis showed that the expression of lncRNA UCA1 in EMS was increased (P<0.01). Knockdown of UCA1 in vitro significantly inhibited the proliferation of endometrial stromal cells (ESCs) and induced autophagy and apoptosis.

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