Long Noncoding RNA UCA1 Is Related to Autophagy and Apoptosis in Endometrial Stromal Cells
长链非编码RNA UCA1与子宫内膜基质细胞自噬和凋亡相关
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作者:Lili Jiang, Yahui Wan, Ziyi Feng, Da Liu, Ling Ouyang, Yan Li, Kuiran Liu
| 期刊: | Frontiers in Oncology | 影响因子: | 3.500 |
| 时间: | 2021 | 起止号: | 2021 Feb 18:10:618472. |
| doi: | 10.3389/fonc.2020.618472 | 研究方向: | 信号转导、细胞生物学 |
| 细胞类型: | 基质细胞 | 信号通路: | Apoptosis、Autophagy |
Conclusion
UCA1 is highly expressed in EMS and promotes the proliferation of ESCs but suppresses autophagy and apoptosis. In EMS, UCA1 may be a prognostic marker and therapeutic target.
Results
qRT-PCR analysis showed that the expression of lncRNA UCA1 in EMS was increased (P<0.01). Knockdown of UCA1 in vitro significantly inhibited the proliferation of endometrial stromal cells (ESCs) and induced autophagy and apoptosis.
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