Significance
In the present study, we performed a 2-DE based proteomic research on HSCR patients, in order to find some clue for the pathomechanism of bowel motility of HSCR disease. As a character of this study, we also compared the expression of altered proteins in ganglionic segment of HSCR patients with that in normal children. Our results showed that some altered proteins found in aganglionic segment had also changed their expression in ganglionic segment comparing with normal children. This result suggested that the ganglionic segment of HSCR patients was not completely normal, and this is important because it provided more information to understand the pathophysiological mechanisms of bowel dysfunction and will help to the therapy of HSCR disease.