The role of enhancer RNAs in epigenetic regulation of gene expression

增强子RNA在基因表达表观遗传调控中的作用

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Abstract

Since the discovery that enhancers can support transcription, the roles of enhancer RNAs have remained largely elusive. We identified that enhancer RNAs interact with and augment bromodomain engagement with acetylated chromatin. Here, we discuss our recent findings and the potential mechanisms underlying the regulation and functions of enhancer RNA-bromodomain associations.

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