ALOX5 promotes autophagy-dependent ferroptosis by activating the AMPK/mTOR pathway in melanoma
ALOX5 通过激活黑色素瘤中的 AMPK/mTOR 通路促进自噬依赖性铁死亡
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作者:Min Wang, Guang Zeng, Bingrui Xiong, Xiaobin Zhu, Jia Guo, Danyang Chen, Shanshan Zhang, Min Luo, Liang Guo, Lin Cai
| 期刊: | Biochemical Pharmacology | 影响因子: | 5.300 |
| 时间: | 2023 | 起止号: | 2023 Jun:212:115554. |
| doi: | 10.1016/j.bcp.2023.115554 | 研究方向: | 信号转导、细胞生物学、肿瘤 |
| 疾病类型: | 黑色素瘤 | 信号通路: | AMPK、Autophagy、mTOR |
Background
Melanoma has become more common, and its therapeutic management has remained challenging in recent decades. The
Conclusion
ALOX5 deficiency was resistant to autophagy and ferroptosis by inhibiting the AMPK/mTOR pathway. Therefore, it can provide new targets and methods for melanoma drug development.
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