Abstract
INTRODUCTION: Parkinson's disease (PD) is a common neurodegenerative disorder. Traditional diagnostic methods, relying on clinical assessment and imaging, are often invasive, costly, and require specialized personnel, posing barriers to early detection. As approximately 90% of PD patients develop vocal impairments, vocal analysis emerges as a promising non-invasive diagnostic tool. However, individual deep learning models are often limited by overfitting and poor generalizability. METHODS: This study proposes a PD classification method using spectrogram feature fusion with pre-trained convolutional neural networks (CNNs). Voice recordings were obtained from 61 PD patients and 70 healthy controls (HC) at the First Affiliated Hospital of Henan University of Science and Technology. Preprocessing the raw speech signals yielded 2,476 spectrograms. Three pre-trained models, DenseNet121, MobileNetV3-Large, and ShuffleNetV2, were used for feature extraction. The output of MobileNetV3-Large was adjusted using a 1 × 1 convolutional layer to ensure dimensional alignment before features were fused via summation. RESULTS: Evaluation using 5-fold cross-validation demonstrated that models employing feature fusion consistently outperformed individual models across all metrics. Specifically, the fusion of MobileNetV3-Large and ShuffleNetV2 achieved the highest accuracy of 95.56% and an AUC of 0.99. Comparative experiments with existing state-of-the-art methods confirmed the competitive performance of the proposed approach. DISCUSSION: The fusion of multi-model features more effectively captures subtle pathological signatures in PD speech, overcoming the limitations of single models. This method provides a reliable, low-cost, and non-invasive tool for auxiliary PD diagnosis, with significant potential for clinical application. The code is available at https://github.com/lvrongfu/pjs.