Abstract
Background/Objectives: In automatic medical image analysis, particularly for diabetic retinopathy, the accuracy of labeled data is crucial, as label noise can significantly complicate the analysis and lead to diagnostic errors. To tackle the issue of label noise in retinal image segmentation, an innovative label correction framework is introduced that combines Confident Learning (CL) with a human-in-the-loop re-annotation process to meticulously detect and rectify pixel-level labeling inaccuracies. Methods: Two CL-oriented strategies are assessed: Confident Joint Analysis (CJA) employing DeeplabV3+ with a ResNet-50 architecture, and Prune by Noise Rate (PBNR) utilizing ResNet-18. These methodologies are implemented on four publicly available retinal image datasets: HRF, STARE, DRIVE, and CHASE_DB1. After the models have been trained on the original labeled datasets, label noise is quantified, and amendments are executed on suspected misclassified pixels prior to the assessment of model performance. Results: The reduction in label noise yielded consistent advancements in accuracy, Intersection over Union (IoU), and weighted IoU across all the datasets. The segmentation of tiny structures, such as the fovea, demonstrated a significant enhancement following refinement. The Mean Boundary F1 Score (MeanBFScore) remained invariant, signifying the maintenance of boundary integrity. CJA and PBNR demonstrated strengths under different conditions, producing variations in performance that were dependent on the noise level and dataset characteristics. CL-based label correction techniques, when amalgamated with human refinement, could significantly enhance the segmentation accuracy and evaluation robustness for Accuracy, IoU, and MeanBFScore, achieving values of 0.9156, 0.8037, and 0.9856, respectively, with regard to the original ground truth, reflecting increases of 4.05%, 9.95%, and 1.28% respectively. Conclusions: This methodology represents a feasible and scalable solution to the challenge of label noise in medical image analysis, holding particular significance for real-world clinical applications.