Abstract
The rapid growth of medical imaging data presents challenges for efficient storage and transmission, particularly in clinical and telemedicine applications where image fidelity is crucial. This study proposes a hybrid deep learning-based image compression framework that integrates Stationary Wavelet Transform (SWT), Stacked Denoising Autoencoder (SDAE), Gray-Level Co-occurrence Matrix (GLCM), and K-means clustering. The framework enables multiresolution decomposition, texture-aware feature extraction, and adaptive region-based compression. A custom loss function that combines Mean Squared Error (MSE) and Structural Similarity Index (SSIM) ensures high perceptual quality and compression efficiency. The proposed model was evaluated across multiple benchmark medical imaging datasets and achieved a Peak Signal-to-Noise Ratio (PSNR) of up to 50.36 dB, MS-SSIM of 0.9999, and an encoding-decoding time of 0.065 s. These results demonstrate the model's capability to outperform existing approaches while maintaining diagnostic integrity, scalability, and speed, making it suitable for real-time and resource-constrained clinical environments.