Abstract
Compressed sensing magnetic resonance imaging (CS-MRI) seeks to recover visual information from subsampled measurements for diagnostic tasks. Traditional CS-MRI methods often separately address measurement subsampling, image reconstruction, and task prediction, resulting in a suboptimal end-to-end performance. In this work, we propose Tackle as a unified co-design framework for jointly optimizing subsampling, reconstruction, and prediction strategies for the performance on downstream tasks. The naïve approach of simply appending a task prediction module and training with a task-specific loss leads to suboptimal downstream performance. Instead, we develop a training procedure where a backbone architecture is first trained for a generic pre-training task (image reconstruction in our case), and then fine-tuned for different downstream tasks with a prediction head. Experimental results on multiple public MRI datasets show that Tackle achieves an improved performance on various tasks over traditional CS-MRI methods. We also demonstrate that Tackle is robust to distribution shifts by showing that it generalizes to a new dataset we experimentally collected using different acquisition setups from the training data. Without additional fine-tuning, Tackle leads to both numerical and visual improvements compared to existing baselines. We have further implemented a learned 4×-accelerated sequence on a Siemens 3T MRI Skyra scanner. Compared to the fully-sampling scan that takes 335 seconds, our optimized sequence only takes 84 seconds, achieving a four-fold time reduction as desired, while maintaining high performance. Our code is available at https://github.com/zihuiwu/TACKLE.