Abstract
Breast cancer is the most common cancer in women. Ultrasound is one of the most used techniques for diagnosis, but an expert in the field is necessary to interpret the test. Computer-aided diagnosis (CAD) systems aim to help physicians during this process. Experts use the Breast Imaging-Reporting and Data System (BI-RADS) to describe tumors according to several features (shape, margin, orientation...) and estimate their malignancy, with a common language. To aid in tumor diagnosis with BI-RADS explanations, this paper presents a deep neural network for tumor detection, description, and classification. An expert radiologist described with BI-RADS terms 749 nodules taken from public datasets. The YOLO detection algorithm is used to obtain Regions of Interest (ROIs), and then a model, based on a multi-class classification architecture, receives as input each ROI and outputs the BI-RADS descriptors, the BI-RADS classification (with 6 categories), and a Boolean classification of malignancy. Six hundred of the nodules were used for 10-fold cross-validation (CV) and 149 for testing. The accuracy of this model was compared with state-of-the-art CNNs for the same task. This model outperforms plain classifiers in the agreement with the expert (Cohen's kappa), with a mean over the descriptors of 0.58 in CV and 0.64 in testing, while the second best model yielded kappas of 0.55 and 0.59, respectively. Adding YOLO to the model significantly enhances the performance (0.16 in CV and 0.09 in testing). More importantly, training the model with BI-RADS descriptors enables the explainability of the Boolean malignancy classification without reducing accuracy.