Abstract
With advancements in large language models, artificial intelligence (AI) is undergoing a paradigm shift where AI models can be repurposed with minimal effort across various downstream tasks. This provides great promise in learning generally useful representations from biomedical corpora, at scale, which would empower AI solutions in healthcare and biomedical research. Nonetheless, our understanding of how they work, when they fail, and what they are capable of remains underexplored due to their emergent properties. Consequently, there is a need to comprehensively examine the use of language models in biomedicine. This review aims to summarize existing studies of language models in biomedicine and identify topics ripe for future research, along with the technical and analytical challenges w.r.t. interpretability. We expect this review to help researchers and practitioners better understand the landscape of language models in biomedicine and what methods are available to enhance the interpretability of their models.