Macrophage folate receptor-targeted antiretroviral therapy facilitates drug entry, retention, antiretroviral activities and biodistribution for reduction of human immunodeficiency virus infections

巨噬细胞叶酸受体靶向抗逆转录病毒疗法促进药物进入、保留、抗逆转录病毒活性和生物分布,从而减少人类免疫缺陷病毒感染

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作者:Pavan Puligujja, Joellyn McMillan, Lindsey Kendrick, Tianyuzi Li, Shantanu Balkundi, Nathan Smith, Ram S Veerubhotla, Benson J Edagwa, Alexander V Kabanov, Tatiana Bronich, Howard E Gendelman, Xin-Ming Liu

From the clinical editor

This team of authors describes a novel method for macrophage folate receptor-targeted antiretroviral therapy. Atazanvir entry, retention, and antiretroviral activities were superior using the presented method, and so was its biodistribution, enabling a more efficient way to address human immunodeficiency virus infections, with a hoped for clinical application in the near future.

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