Abstract
OBJECTIVE: Brain parcellation is an essential aspect of computational neuroimaging research and deals with segmenting the brain into (possibly overlapping) sub-regions employed to study brain anatomy or function. In the context of functional parcellation, brain organization which is often measured via temporal metrics such as coherence, is highly dynamic. This dynamic aspect is ignored in most research, which typically applies anatomically based, fixed regions for each individual, and can produce misleading results. METHODS: In this work, we propose a novel spatio-temporal-network (5D) brain parcellation scheme utilizing a deep residual network to predict the probability of each voxel belonging to a brain network at each point in time. RESULTS: We trained 53 4D brain networks and evaluate the ability of these networks to capture spatial and temporal dynamics as well as to show sensitivity to individual or group-level variation (in our case with age). CONCLUSION: The proposed system generates informative spatio-temporal networks that vary not only across individuals but also over time and space. SIGNIFICANCE: The dynamic 5D nature of the developed approach provides a powerful framework that expands on existing work and has potential to identify novel and typically ignored findings when studying the healthy and disordered brain.