Environmental Exposure of Arsenic in Groundwater Associated to Carcinogenic Risk in Underweight Children Exposed to Fluorides

地下水中砷的环境暴露与接触氟化物的体重不足儿童的致癌风险相关

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作者:Nelly Molina-Frechero, Martina Nevarez-Rascón, Omar Tremillo-Maldonado, Marcela Vergara-Onofre, Rey Gutiérrez-Tolentino, Enrique Gaona, Enrique Castañeda, Lizet Jarquin-Yañez, Ronell Bologna-Molina

Background

The

Conclusions

The children are at risk to develop chronic systemic effects due to ingestion of As from water.

Methods

The As content was quantifed in the water supply sources for human use and its intake was estimated in Mezquital population, southern Durango. With the data obtained, the hazard quotient (HQ) was calculated to determine the non-carcinogenic risk to develop chronic systemic effects in underweight children. The Environmental Protection Agency (EPA) reference health values estimating As exposure risk are from 0.0003 mg/kg/day (non-carcinogenic) to 1.5 mg/kg/day (carcinogenic risk).

Results

The analyzed waters presented as concentrations that varied from 0.3 to 10.2 µg/L, with a mean of 7.35 µg/L (CI 95% 6.27-8.38). The exposure dose was 0.4 to 1.36, and the HQ was 1.90 to 6.48 mg/kg/day, the estimated carcinogenic risk from adults varied from 1.28 to 4.37E-4, with values of 3.74-4.37E-4 mg/kg/day in central area. Conclusions: The children are at risk to develop chronic systemic effects due to ingestion of As from water.

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