LKB1 acts as a critical brake for the glucagon-mediated fasting response
LKB1 是胰高血糖素介导的禁食反应的关键制动器
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作者：Suehelay Acevedo-Acevedo, Megan L Stefkovich, Sun Woo Sophie Kang, Rory P Cunningham, Constance M Cultraro, Natalie Porat-Shliom
Conclusion
Our findings show that LKB1 acts as a brake to the glucagon-mediated fasting response, resulting in "periportalization" of the hepatic lobule and whole-body metabolic inefficiency. These findings reveal a mechanism by which hepatic metabolic compartmentalization is regulated by nutrient-sensing.
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