Abstract
BACKGROUND: Mother's voice is a salient auditory stimulus commonly experienced during early development; after birth, characteristic acoustic modulations of mothers' infant-directed speech (IDSpeech) and singing (IDSinging) contribute to neurodevelopment. For preterm infants, early separation leads to decreased exposure to mother's voice; the impact on maternal ability to produce IDSpeech/IDSinging and infant perception of mother's voice is unknown. METHODS: Fifty mother/preterm-infant dyads were enrolled in this prospective cohort study. Forty-four mothers recorded Twinkle, Twinkle Little Star in coached adult-directed speech (ADSpeech), IDSpeech, and IDSinging. Between 34.0-36.9w CGA, infants underwent high-density EEG during exposure to their mother's voice recordings. Acoustic features of mothers' voice and infant cortical response were analyzed and correlated. RESULTS: Acoustic features of recorded maternal ADSpeech, IDSpeech, and IDSinging were significantly different. In 33 infants with EEG, mean fundamental frequency and speech production rate (SPR) variability correlated with infant responses to ADSpeech; SPR and SPR variability correlated with IDSpeech; SPR correlated with IDSinging. Correlations were found at differing scalp locations for speech versus singing. CONCLUSION: Mothers of hospitalized preterm infants differentially modulate their voice during coached recorded language; features can then be differentiated by their preterm infants thus presenting opportunities for targeted interventions when parents cannot be present. IMPACT: Mothers of preterm infants can record their voice with acoustically quantifiable characteristics of infant-directed singing and speech, even when not at their infant's bedside. Recorded adult- and infant-directed speech stimuli are differentially processed in the brains of hospitalized preterm infants. The ability for mothers to create acoustically-distinct infant-directed speech in the absence of their infant may be driven by coaching to achieve an approximated sense of connection with their infant.