New composition of tungsten has a broad range of antiviral activity

钨的新成分具有广泛的抗病毒活性

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作者:Hranush Avagyan, Anaida Mirzoyan, Ferdinand Mirzoyan, Roza Izmailyan, Sona Hakobyan, Henry Voskanyan, Zara Semerjyan, Aida Avetisyan, Hranush Arzumanyan, Elena Karalova, Liana Abroyan, Lina Hakobyan, Nane Bayramyan, Nazeli Gevorgyan, Alexander Karalyan, Zaven Karalyan

Abstract

The water-based combination of two inorganic chemical compounds such as sodium tungstate dihydrate-Na2WO4 × 2H2O and Aluminum sulfate octadecahydrate-Al2 (SO4) 3 × 18H2O that we have conditionally named 'Vomifal' has a broad antiviral activity in various DNA and RNA viruses, including Human Herpes Virus (HHV), African Swine Fever Virus (ASFV), Vaccinia Virus (VV), Hepatitis C Virus (HCV), Foot and Mouth Disease Virus (FMDV), Influenza A virus (A/Aichi/2/68 (H3N2)). In vitro and In vivo assays in several tissue cultures as well as in laboratory animals, conformed 'Vomifal' has a very low toxicity and the antiviral properties partially are due to its ability to induce gamma-IFN. Based on the results obtained, we can assume the presence of at least two mechanisms of the antiviral action of the studied drug. First or early stage - an unknown mechanism, possibly related to the effect on cellular receptors. Second or late stage - main antiviral properties probably associated with an interferonogenic effect.

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