Spatial localization of endothelial cells in heterotypic spheroids influences Notch signaling
异型球体中内皮细胞的空间定位影响 Notch 信号传导
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作者：Charlotte E Vorwald, Shreeya Joshee, J Kent Leach
Key messages
• Endothelial cell (EC) localization can be controlled in co-culture EC-MSC spheroids. • Mixed spheroids exhibit consistent networks compared to shell counterparts. • Differences in NOTCH3 were observed between mixed and shell spheroids. • NOTCH3 may be a necessary target for improved vasculogenic potential.
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