Abstract
This study examines how digital tools can redesign primary healthcare systems, focusing on the digital transformation activities implemented by the Avança Saúde SP program in São Paulo, Brazil. With investments of US$200 million, the 5-year program (2019-2024) aimed to expand coverage and improve primary healthcare for the São Paulo population through investments in technology, management and infrastructure. Based on interviews with healthcare professionals and public officials, this case outlines the initiative's use of integrated systems for administrative and care services, telecare and risk management. The findings suggest that these actions have contributed to a more resilient, integrated and data-driven healthcare network in São Paulo. The program's combination of strategic leadership, interoperable digital platforms and integrated management systems demonstrates a potentially replicable model for strengthening primary healthcare resilience, offering valuable insights for other cities seeking to enhance health system preparedness, equity and efficiency.