Abstract
Blockchain is a decentralized, secure, and immutable public ledger that offers significant benefits over conventional centralized systems by preventing data breaches and cyber-attacks. It has a great potential to improve data security, privacy, and interoperability in healthcare and biomedical research. This review discusses the basic principles and the historical evolution of blockchain and evaluates the implications of blockchain for the existing healthcare infrastructure. It also highlights blockchain technology's advantages in electronic health records, supply chain management, clinical trials, and telemedicine. However, this technology faces several hurdles, including regulatory issues, technical complexity, and economic costs, which suggest a gradual adoption over time. In addition, the review emphasizes its ability to ensure data integrity, enhance collaboration, and protect intellectual property in biomedical research. This review shows that blockchain can enhance healthcare data management by providing secure, efficient, and patient-centric solutions. Furthermore, it also discusses the implications of blockchain for the future of healthcare and biomedical research and suggests that ongoing research and interdisciplinary approaches are essential for overcoming current barriers and realizing the full potential of this technology. Future research should focus on developing privacy-preserving hybrid data storage solutions that comply with international laws and regulations, thus enhancing the sustainability and scalability of this technology in healthcare.