Abstract
Cyclodextrin (CD)-hydrogel hybrids have emerged as versatile and multifunctional drug delivery systems, offering enhanced solubility, controlled drug release, and improved bioavailability. By combining the inclusion complexation properties of CDs with the swelling and retention capabilities of hydrogels, these hybrid systems overcome key challenges in conventional drug formulations. This review explores CD composition, hydrogel polymer selection, fabrication techniques, key drug release factors, and real-world therapeutic applications. Additionally, the latest advancements in stimuli-responsive hydrogels, nanogels, and microneedle-based drug delivery are discussed. While CD-hydrogel systems demonstrate significant potential, scalability, regulatory hurdles, and clinical translation remain key challenges. Future research should focus on smart hydrogels, improved drug loading strategies, and enhanced clinical validation to bridge the gap between laboratory innovations and commercial applications.