Dissection of the Major Hematopoietic Quantitative Trait Locus in Chromosome 6q23.3 Identifies miR-3662 as a Player in Hematopoiesis and Acute Myeloid Leukemia

染色体 6q23.3 上主要造血数量性状基因座的解剖确定 miR-3662 是造血和急性髓系白血病的参与者

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作者:Sophia E Maharry, Christopher J Walker, Sandya Liyanarachchi, Sujay Mehta, Mitra Patel, Maryam A Bainazar, Xiaomeng Huang, Malori A Lankenau, Kevin W Hoag, Parvathi Ranganathan, Ramiro Garzon, James S Blachly, Denis C Guttridge, Clara D Bloomfield, Albert de la Chapelle, Ann-Kathrin Eisfeld

Significance

The characterization of miR-3662 has identified a new actor in the prominent hematopoietic quantitative trait locus in chromosome 6q23.3. The mechanistic insights into miR-3662's function may reveal novel or only partially known pathways for normal and malignant hematopoietic cell proliferation. Cancer Discov; 6(9); 1036-51. ©2016 AACR.This article is highlighted in the In This Issue feature, p. 932.

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