Abstract
Like several countries, Spain experienced a multi wave pattern of COVID-19 pandemic over more than one year period, between spring 2020 and spring 2021. The transmission of SARS-CoV-2 pandemics is a multi-factorial process involving among other factors outdoor environmental variables and viral inactivation.This study aims to quantify the impact of climate and air pollution factors seasonality on incidence and severity of COVID-19 disease waves in Madrid metropolitan region in Spain. We employed descriptive statistics and Spearman rank correlation tests for analysis of daily in-situ and geospatial time-series of air quality and climate data to investigate the associations with COVID-19 incidence and lethality in Madrid under different synoptic meteorological patterns. During the analyzed period (1 January 2020-28 February 2021), with one month before each of three COVID-19 waves were recorded anomalous anticyclonic circulations in the mid-troposphere, with positive anomalies of geopotential heights at 500 mb and favorable stability conditions for SARS-CoV-2 fast diffusion. In addition, the results reveal that air temperature, Planetary Boundary Layer height, ground level ozone have a significant negative relationship with daily new COVID-19 confirmed cases and deaths. The findings of this study provide useful information to the public health authorities and policymakers for optimizing interventions during pandemics.