Abstract
OBJECTIVES: The aim of this study was to investigate the relationship between fall frequency and progressive supranuclear palsy (PSP) severity, walking ability, balance function, cognitive function, and frontal lobe function in patients with PSP. METHODS: The study included 54 patients with PSP. Multiple logistic regression analysis was conducted to examine whether PSP severity, walking ability, balance function, cognitive function, and frontal lobe function after discharge were associated with fall frequency (falling two or more times per month). Balance function was assessed using the Berg Balance Scale and Mini-Balance Evaluation Systems Test (Mini-BESTest), with each used as an independent variable in separate models for association analysis. The Mini-BESTest showed a significant association, and its subitems were further analyzed using multiple logistic regression analysis. RESULTS: A significant association was observed between the Mini-BESTest and fall frequency, and among its subitems, anticipatory postural adjustments were significantly associated with fall frequency. CONCLUSIONS: In patients with PSP characterized by impaired postural reflexes, the anticipatory postural adjustment ability may be associated with fall frequency.