Abstract
BACKGROUND: The biodistribution of PSMA-ligands is of interest in radionuclide therapy planning. We investigated the variability of [(18)F]PSMA-1007 uptake in organs at risk and in relation to tumour burden in prostate cancer patients. METHODS: A total of 1086 patients who underwent PSMA PET-CT for staging or recurrence of prostate cancer were included. Total lesion volume (TLV) and total lesion uptake (TLU) were calculated from manual segmentations. The mean standardized uptake value (SUV(mean)) in the organs at risk kidneys, liver, parotid glands and spleen was obtained. Correlations between TLV/TLU and SUV(mean) in normal tissues were calculated using Spearman rank correlation. SUV(mean) in normal tissues was stratified into groups based on TLV. RESULTS: The median (IQR) SUV(mean) of the kidneys, liver, parotid glands, and spleen was 13.1 (IQR 4.6), 11.8 (4.4), 18.6 (6.8) and 11.3 (5.8), respectively. The median TLV was 3.8 cm(3) (9.7) and median TLU was 31.2 cm(3) (106.3). There was no significant correlation between TLV or TLU and SUV(mean) for the liver, parotid glands, or spleen, but a weak negative correlation between TLV/TLU and SUV(mean) in the kidneys (r = -0.011, p = 0.0005; r = -0.09, p = 0.003). There was a tendency towards a lower SUV(mean) in the kidneys and parotid glands in patients with a very high TLV. CONCLUSIONS: There was a large uptake variability in organs at risk, which demonstrates the need for individual pretherapy dosimetry. There may be a tumour sink effect in the kidneys and parotid glands in patients with a very high TLV.