Abstract
BACKGROUND: Persistent lung consolidation and cavitary lesions are recognized sequelae of severe pneumonia, particularly in patients with prior oncologic or radiation-related lung injury. Platelet-rich plasma (PRP) contains growth factors and cytokines that promote tissue repair and immune modulation, yet its pulmonary application remains largely unexplored. CASE PRESENTATION: A woman in her mid-40s with a history of stage IV right-lower-lobe non-small-cell lung cancer (NSCLC) in long-term remission developed severe pneumonia while overseas. Six weeks after discharge, a low-dose CT revealed persistent right-upper-lobe consolidation with internal lucency. She administered nebulized autologous PRP for 4 weeks using a compressor-based nebulizer. RESULTS: Serial CT imaging demonstrated rapid reduction and eventual resolution of the consolidation with closure of a cavitary defect. The patient experienced no bronchial irritation or adverse effects. CONCLUSION: Nebulized autologous PRP was temporally associated with radiologic resolution of a post-infective cavitary lesion in a previously irradiated lung. This finding supports further study of PRP's regenerative potential in pulmonary disease.