Abstract
OBJECTIVE: This pilot randomized controlled trial explored feasibility, and preliminary effects from remotely delivered high- versus low-intensity exercise prior to balance training for people with Spinocerebellar Ataxia (SCA). METHODS: Twenty participants with SCA (types 1, 2, 3, or 6) were randomized to high- or low-intensity exercise (30 min), followed by balance training (30 min), delivered via telehealth twice-weekly for 8-weeks. Exercises were progressive and individualized based on ataxia severity, mobility, and home equipment. Outcomes included disease-specific measures (Scale for Assessment and Rating of Ataxia at home, Cerebellar Cognitive Affective Syndrome Scale), and fatigue (Fatigue Severity Scale) assessed at baseline, mid- and post-intervention. RESULTS: Eighteen participants completed the intervention with high adherence. Both groups improved on disease-specific measures, with greater gains in cognition and reduced fatigue in the low-intensity group. CONCLUSIONS: Remote delivery of exercise and balance training is feasible in SCA. Fatigue may limit tolerability of higher exercise intensities. National Institutes of Health Clinical Trials Registration Number: NCT05826171.