Hepatic Vasculopathy and Regenerative Responses of the Liver in Fatal Cases of COVID-19

新冠肺炎死亡病例中的肝血管病变和肝脏再生反应

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Abstract

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infects the nasopharynx and lungs and causes coronavirus disease-2019 (COVID-19). It may impact the heart, brain, kidney, and liver.(1) Although functional impairment of the liver has been correlated with worse clinical outcomes, little is known about the pathophysiology of hepatic injury and repair in COVID-19.(2)(,)(3) Histologic evaluation has been limited to small numbers of COVID-19 cases with no control subjects(2)(,)(4) and demonstrated largely heterogeneous patterns of pathology.(2)(,)(3).

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