Does frank diabetes in first-degree relatives of a pregnant woman affect the likelihood of her developing gestational diabetes mellitus or nongestational diabetes?

孕妇一级亲属患有糖尿病是否会影响其患妊娠期糖尿病或非妊娠期糖尿病的几率?

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Abstract

OBJECTIVE: We sought to examine the associations between patterns of family histories of diabetes and a history of gestational diabetes mellitus (hGDM). STUDY DESIGN: Parous women participating in the National Health and Nutrition Examination Survey III (n=4566) were classified as having hGDM only, diagnosed diabetes, or neither. Family history of diabetes was categorized as: maternal only, paternal only, biparental, and sibling only. The covariate-adjusted prevalence and odds of having hGDM were estimated. RESULTS: Compared to women without a family history of diabetes, women with a maternal (odds ratio [OR], 3.0; 95% confidence interval [CI], 1.2-7.3), paternal (OR, 3.3; 95% CI, 1.1-10.2), or sibling (OR, 7.1; 95% CI, 1.6-30.9) history of diabetes had greater odds of hGDM, after adjustment for age and race/ethnicity. CONCLUSION: Women with a sibling history of diabetes were more likely to have hGDM than women with other family history patterns.

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