Abstract
The relationship between brain microstructure and aging has been the subject of intense study, with diffusion MRI perhaps the most effective modality for elucidating these associations. Here, we used the mean apparent propagator (MAP)-MRI framework, which is suitable to characterize complex microstructure, to investigate age-related cerebral differences in a cohort of cognitively unimpaired participants and compared the results to those derived using diffusion tensor imaging. We studied MAP-MRI metrics, among them the non-Gaussianity (NG) and propagator anisotropy (PA), and established an opposing pattern in white matter of higher NG alongside lower PA among older adults, likely indicative of axonal degradation. In gray matter, however, these two indices were consistent with one another, and exhibited regional pattern heterogeneity compared to other microstructural parameters, which could indicate fewer neuronal projections across cortical layers along with an increased glial concentration. In addition, we report regional variations in the magnitude of age-related microstructural differences consistent with the posterior-anterior shift in aging paradigm. These results encourage further investigations in cognitive impairments and neurodegeneration.