Trend and early clinical outcomes in patients with preexisting atrial fibrillation undergoing isolated mitral valve surgery with or without surgical ablation

既往存在房颤的患者接受单纯二尖瓣手术(伴或不伴外科消融)的趋势和早期临床结果

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Abstract

IntroductionEuropean and American guidelines recommend concomitant surgical ablation for atrial fibrillation (AF) in patients undergoing mitral valve surgery. There is evidence that this intervention reduces the incidence of early and mid-term incidence of AF post-operatively. We aim to report the trend and early clinical outcomes in this cohort of patients in the United Kingdom.MethodThis study included all patients with underlying atrial fibrillation who underwent first-time, elective, or urgent isolated mitral valve repair/replacement from 2011 to April 2019. We evaluated the trend and early clinical outcomes between patients who did/did not receive surgical AF ablation and examined associated factors.ResultsA total of 3497 patients were included, with a median age of 70.6 years old (IQR: 63.1, 76.5), and 52.67% were male. The number of isolated mitral valve surgery performed ranges between 388 to 464 during the study period. The mitral valve repair rate was 62%. The overall AF ablation rate was 27.71% (Range: 16.74%-33.33%). After inverse propensity score matching, patients who underwent AF ablation had a significantly longer cardiopulmonary bypass (125 vs 99 mins, p < .001) and aortic cross-clamp time (92 vs 73 mins, p < .001). However, there was no difference in in-hospital mortality (2.03% vs 1.80%, p = .69), return to theatre for bleeding (5.82% vs 7.44%, p = .11), post-operative stroke (0.61% vs 0.48%, p = .11), post-operative dialysis (2.54% vs 2.40%, p = .83) and deep sternal wound infection (0.56% vs 0.88%, p = .34).ConclusionPatients with pre-existing atrial fibrillation undergoing concomitant surgical ablation during mitral valve intervention had a longer cardiopulmonary bypass and cross-clamp time without compromising short-term clinical outcomes. Long-term outcomes are required to examine the potential lasting benefit of surgical ablation.

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