Abstract
The oral microbiome plays a crucial role in maintaining health, with Streptococcus salivarius recognized for its beneficial probiotic functions, including inhibiting pathogenic bacteria and supporting immune regulation, particularly in healthy individuals. While research on S. salivarius has primarily focused on strains originating from non-Asian populations, particularly New Zealand, with some studies also reporting European strains, research on strains originating from Korea has been notably lacking. This dataset provides the complete genome sequences and transcriptomic profiles of 12 S. salivarius strains isolated from healthy Korean individuals. PacBio SMRTbell technology was employed for genome sequencing. Our dataset includes transcriptomic data that reveal functional gene expression patterns under standard growth conditions. The strains analyzed here are particularly valuable as each exhibits a unique interaction with Fusobacterium nucleatum, a pathogen associated with periodontal disease and colorectal cancer, collectively demonstrating diverse patterns of interaction. By offering comprehensive data on strain variation, this resource can serve as a valuable tool for research aimed at understanding and utilizing beneficial oral bacteria.