Assessing Delays in Time to Diagnosis of Duchenne Muscular Dystrophy: A Survey of Current Primary Care Practices

评估杜氏肌营养不良症诊断时间延误情况:一项针对当前基层医疗实践的调查

阅读:2

Abstract

BACKGROUND:  Duchenne muscular dystrophy (DMD) is a progressive neuromuscular disorder in which delayed recognition remains a significant challenge in primary care. Early identification remains a significant challenge in primary care. Early identification is essential to enable timely referral, diagnostic testing, and initiation of supportive and disease-modifying therapies. However, variability in developmental screening practices and uncertainty regarding appropriate diagnostic evaluation may contribute to ongoing delays. AIM: To investigate current practices in diagnosing and managing DMD, focusing on screening tools for developmental milestones and the referral process for suspected cases, and to understand the challenges and opportunities in early identification, diagnosis, and long-term care for individuals with DMD. METHODS: A 13-item needs survey was developed by a multidisciplinary team, including pediatricians and a pediatric neuromuscular specialist, to ensure content relevance and clarity. The face and content validity of the survey were established through expert review before distribution. This survey was then distributed nationally to 325 healthcare professionals using a mixed approach of open and closed-ended questions to evaluate screening tools used for developmental milestones, referral processes for suspected DMD diagnosis, and their involvement in ongoing DMD management. RESULTS: A total of 90% of clinicians were aware of checking creatinine kinase levels for DMD diagnosis; however, only 17% used it as a primary action for suspected motor delays. Approximately one-third of respondents did not use a primary screening tool for developmental delays, often opting for a "wait and see" approach instead. Thematic analysis of open-ended responses highlighted four main roles perceived by clinicians in DMD management: early detection, care coordination, referrals, and supporting patients and caregivers. CONCLUSIONS: Clinicians play a crucial role in coordinating care for DMD patients, but there are gaps in standardized screening and diagnosis practices. Improved education for primary care clinicians is necessary to enhance the recognition and management of neuromuscular disorders, facilitating early access to therapies, and improving patient outcomes.

特别声明

1、本页面内容包含部分的内容是基于公开信息的合理引用;引用内容仅为补充信息,不代表本站立场。

2、若认为本页面引用内容涉及侵权,请及时与本站联系,我们将第一时间处理。

3、其他媒体/个人如需使用本页面原创内容,需注明“来源:[生知库]”并获得授权;使用引用内容的,需自行联系原作者获得许可。

4、投稿及合作请联系:info@biocloudy.com。