Sudden appearance of invalidating dyskinesia-dystonia and off fluctuations after the introduction of levodopa in two dopaminomimetic drug naive patients with stage IV Parkinson's disease

两名未接受过多巴胺能药物治疗的IV期帕金森病患者在引入左旋多巴后，突然出现严重的运动障碍-肌张力障碍和“关期”波动。