Vitamin D alleviates acute graft-versus-host disease through promoting the generation of Foxp3+ T cells

维生素 D 通过促进 Foxp3+ T 细胞的产生来缓解急性移植物抗宿主病

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作者:Chuangye Ni, Xiaojie Gan, Xu Li, Han Sun, Zhen Chen, Hao Lu

Background

Acute graft-versus-host disease (aGVHD) is a medical complication which may result in significant morbidity and mortality after transplantation. The

Conclusions

This analysis indicated that the effect of 1α,25(OH)2D3 is mediated in part by improving the number of Tregs. 1α,25(OH)2D3 administration thus represents a viable approach for treating aGVHD.

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