Inflammation Associates With Impaired Small Arterial Elasticity Early in HIV Disease

炎症与艾滋病早期小动脉弹性受损有关

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作者:Tess E Peterson, Katherine Huppler Hullsiek, Nicole Wyman Engen, Nagalingeswaran Kumarasamy, Anne-Mette Lebech, Angelike Liappis, Antonios Papadopoulos, Mark N Polizzotto, Pamela J Schreiner, Daniel Duprez, Jason V Baker; INSIGHT START (Strategic Timing of AntiRetroviral Treatment) Study Group

Abstract

We estimated small arterial elasticity and used linear regression to evaluate its association with inflammatory biomarkers among antiretroviral therapy-naïve, HIV-positive patients with high CD4+ counts. After adjustment, high-sensitivity C-reactive protein and interleukin-6 were inversely associated with small arterial elasticity. These data suggest that systemic inflammation may contribute to vascular dysfunction even in very early HIV disease.

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