Abstract
BACKGROUND: Sepsis-associated acute kidney injury is common in critically ill patients and is strongly associated with adverse outcomes. OBJECTIVE: To explore the diagnostic value and prognostic significance of microRNA (miRNA) miR-210, serum creatinine (Scr), neutrophil gelatinase-associated lipocalin (NGAL), blood urea nitrogen (BUN), cystatin C (CysC), and sequential organ failure assessment (SOFA) scores in patients with sepsis-associated acute kidney injury. DESIGN: This was a retrospective study. SETTING: This study was performed in the Department of Intensive Care Unit at Shengli Oilfield Central Hospital. PARTICIPANTS: A total of 81 sepsis patients treated at our hospital from April to November 2021 were chosen and divided into two groups according to whether acute kidney injury was present. INTERVENTIONS: The levels of miR-210, Scr, NGAL, BUN, CysC, and SOFA scores were detected, and an ROC curve was implemented to assess the diagnostic value. The risk factors influencing prognosis were assessed by binary logistic regression. PRIMARY OUTCOME MEASURES: (1) Levels of miR-210, Scr, NGAL, BUN, CysC, and SOFA scores; (2) Diagnostic value of miR-210, Scr, NGAL, BUN, CysC, and SOFA scores; (3) Risk factors influencing the prognosis of patients with sepsis-associated acute kidney injury. RESULTS: Compared with sepsis patients, levels of miR-210, Scr, NGAL, BUN, CysC, and SOFA scores in patients with sepsis-associated acute kidney injury were elevated (p < 0.001). The ROC curve indicated that miR-210 had the highest diagnostic value in patients with sepsis-associated acute kidney injury, with an AUC of 0.913 and sensitivity and specificity of 92.21 and 91.37%, respectively (p < 0.001). The expressions of miR-210, NGAL, CysC, and SOFA scores in the dead patients were significantly elevated compared to the survival cases (p < 0.05). MiR-210 levels and SOFA scores affected the prognosis of patients with sepsis-associated acute kidney injury. CONCLUSION: Our study demonstrated that miR-210, Scr, NGAL, BUN, CysC, and SOFA scores had significant diagnostic value in patients with sepsis-associated acute kidney injury and that miR-210 and SOFA scores had good prognostic value.