Abstract
Aplasia cutis congenita (ACC) is a rare congenital disorder characterized by the absence at birth, of skin, dermal appendages, and, in some cases, subcutaneous tissues. The scalp is the most commonly affected area. Usually, particularly after conservative or minimally invasive management at birth, it results in an area of alopecia. We describe a case of post-ACC alopecia of the scalp treated with follicular unit transplantation, combined with platelet-rich plasma and fat grafting. In our patient, this combined therapeutic strategy induced radical modifications of hair follicles, skin quality, and also sensitivity of the affected area.