Abstract
The rising global incidence of diabetes has heightened the demand for prevention strategies that are both effective and environmentally sustainable. In this context, dietary supplements obtained from food processing by-products have emerged as promising candidates, combining high nutritional value with the potential to reduce food waste. These by-products contain abundant bioactive compounds, such as antioxidants, dietary fiber, vitamins, and minerals, that have been associated with improved glycemic regulation. Their beneficial effects are mediated through several interconnected biological mechanisms, including enhanced insulin sensitivity, attenuation of oxidative stress, and modulation of inflammatory pathways. The efficacy of these supplements is supported by findings from preclinical models, clinical trials, and meta-analyses, which also allow comparison with standard antidiabetic interventions. Alongside these findings, considerations related to safety, toxicity, and the regulatory framework are critical for their integration into preventive health strategies. Furthermore, market trends, technological challenges in supplement formulation, and ethical issues surrounding the valorization of food waste are key factors influencing their development and acceptance. Together, these insights underscore the dual therapeutic and ecological potential of food by-product-derived supplements in diabetes prevention, while identifying essential avenues for future research and innovation.