Identification of broad neutralizing antibodies against Omicron subvariants from COVID-19 convalescents and vaccine recipients

• BF.7 and BQ.1, escaped most neutralizing antibodies isolated from the recovered COVID-19 individuals and vaccine recipients. • Five potent mAbs were identified that showed a broad neutralizing profile to Omicron subvariants and other VOCs. • These broad neutralizing antibodies targeted the RBD of the spike protein, competing with ACE2 for binding.