Abstract
Background/Objectives: The aim of the present study was to identify preoperative functional and anatomical parameters that better predict postoperative best corrected visual acuity (BCVA) after full-thickness macular hole (MH) surgery during long-term follow-up. Methodology: Initial visual outcomes, medical history, retinal imaging data, microperimetry and mfERG measurements were collected to characterise functional and morphological macular status. Results: Among the study subjects, 22 presented with a BCVA > 0.5, and 20 presented with a BCVA ≤ 0.5 at the final visit. Multivariate regression analysis revealed that a smaller minimum MH diameter (OR = 0.98; 95% CI = 0.87-0.99; p = 0.004) and a shorter disease duration (OR =0.11; 95% CI = 0.02-0.53; p = 0.005) were predictors of postoperative long-term BCVA > 0.5. Baseline P wave amplitudes in the central ring on mfERG were positively correlated with postoperative BCVA gain (Rs = +0.53, p = 0.001). Conclusions: Our findings corroborate the significance of hole diameter measurements for postoperative visual outcomes and support the rationale of early intervention.