Abstract
OBJECTIVES: To develop a machine learning-based prediction model using clinical data from the first 24 h of ICU admission to enable rapid screening and early intervention for sepsis patients. METHODS: This multicenter retrospective cohort study analyzed electronic medical records of sepsis patients using machine learning methods. We evaluated model performance in predicting sepsis outcomes within the first 24 h of ICU admission across US and Chinese healthcare settings. RESULTS: From 31 clinical features, machine learning models demonstrated significantly better predictive performance than traditional approaches for sepsis outcomes. While linear regression achieved low test scores (0.25), machine learning methods reached scores of 0.78 and AUCs above 0.8 in testing. Importantly, these models maintained robust performance (scores 0.63-0.77) in external validation. CONCLUSIONS: The application of machine learning-based prediction models for sepsis could significantly improve patient outcomes through early detection and timely intervention in the critical first 24 h of ICU admission, supporting clinical decision-making.