Abstract
BACKGROUND: Corona virus disease 2019 (COVID-19) reinfection, particularly short-term reinfection, poses challenges to the management of rheumatic diseases and may increase adverse clinical outcomes. This study aims to develop machine learning models to predict and identify the risk of short-term COVID-19 reinfection in patients with rheumatic diseases. METHODS: We developed four prediction models using explainable machine learning to assess the risk of short-term COVID-19 reinfection in 543 patients with rheumatic diseases. Psychological health was evaluated using the Functional Assessment of Chronic Illness Therapy Fatigue (FACIT-F) scale, the Patient Health Questionnaire-9 (PHQ-9), the Generalized Anxiety Disorder 7-item (GAD-7) questionnaire, and the Pittsburgh Sleep Quality Index (PSQI) scale. Health status and disease activity were assessed using the EuroQol-5 Dimension-3 Level (EQ-5D-3L) descriptive system and the Visual Analogue Score (VAS) scale. The model performance was assessed by Area Under the Receiver Operating Characteristic Curve (AUC), Area Under the Precision-Recall Curve (AUPRC), and the geometric mean of sensitivity and specificity (G-mean). SHapley Additive exPlanations (SHAP) analysis was used to interpret the contribution of each predictor to the model outcomes. RESULTS: The eXtreme Gradient Boosting (XGBoost) model demonstrated superior performance with an AUC of 0.91 (95% CI 0.87-0.95). Significant factors of short-term reinfection included glucocorticoid taper (OR = 2.61, 95% CI 1.38-4.92), conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) taper (OR = 2.97, 95% CI 1.90-4.64), the number of symptoms (OR = 1.24, 95% CI 1.08-1.42), and GAD-7 scores (OR = 1.07, 95% CI 1.02-1.13). FACIT-F scores were associated with a lower likelihood of short-term reinfection (OR = 0.95, 95% CI 0.93-0.96). Besides, we found that the GAD-7 score was one of the most important predictors. CONCLUSION: We developed explainable machine learning models to predict the risk of short-term COVID-19 reinfection in patients with rheumatic diseases. SHAP analysis highlighted the importance of clinical and psychological factors. Factors included anxiety, fatigue, depression, poor sleep quality, high disease activity during initial infection, and the use of glucocorticoid taper were significant predictors. These findings underscore the need for targeted preventive measures in this patient population.