Abstract
BACKGROUND: The study investigated the predictive value of tumor angiogenesis observed by (18)F-ALF-NOTA-PRGD2 II (denoted as (18)F-Alfatide II) positron emission tomography (PET)/computed tomography (CT) before concurrent chemoradiotherapy (CCRT) for treatment response and survival among patients with locally advanced non-small cell lung cancer (LA-NSCLC). METHODS: Patients with unresectable stage IIIA or IIIB NSCLC (AJCC Cancer Staging 7th Edition) who received CCRT were included in this prospective study. All patients had undergone (18)F-Alfatide PET/CT scanning before CCRT, and analyzed parameters included maximum uptake values (SUV(max)) of primary tumor (SUV(P)) and metastatic lymph nodes (SUV(LN)) and mean uptake value of blood pool (SUV(blood)). Tumor-to-background ratios (TBRs) and changes in tumor diameter before and after CCRT (ΔD) were calculated. The ratios of SUV(P) to SUV(blood), SUV(LN) to SUV(blood), and SUV(P) to SUV(LN) were denoted as TBR(P), TBR(LN), and T/LN. Short-term treatment response, progression-free survival (PFS), and overall survival (OS) were evaluated. RESULTS: Of 38 enrolled patients, 28 completed CCRT. SUV(P), SUV(LN), TBR(P), TBR(LN) and T/LN showed significant correlation with PFS (all P < 0.05). SUV(P) was negatively correlated with OS (P = 0.005). SUV(P) and TBR(P) were higher in non-responders than in responders (6.55 ± 2.74 vs. 4.61 ± 1.94, P = 0.039; 10.49 ± 7.58 vs. 7.73 ± 6.09, P = 0.023). ΔD was significantly greater in responders (2.78 ± 1.37) than in non-responders (-0.16 ± 1.33, P < 0.001). Exploratory receiver operating characteristic curve analysis identified TBR(P) (area under the curve [AUC] = 0.764, P = 0.018), with a cutoff value of 6.52, as the only parameter significantly predictive of the response to CCRT, with sensitivity, specificity, and accuracy values of 71.43%, 78.57%, and 75.00%, respectively. ROC curve analysis also identified SUV(P) (AUC = 0.942, P < 0.001, cutoff value 4.64) and TBR(P) (AUC = 0.895, P = 0.001, cutoff value 4.95) as predictive of OS with high sensitivity (84.21%, 93.75%), specificity (100.00%, 66.67%), and accuracy (89.29%, 82.14%). CONCLUSIONS: Evaluation of tumor angiogenesis by (18)F-Alfatide II at baseline may be useful in predicting the short-term response to CCRT as well as PFS and OS in patients with LA-NSCLC.