Abstract
Background Female sexual dysfunction (FSD) affects a significant portion of the female population, negatively impacting quality of life. New therapeutic approaches, such as the combination of laser therapy and platelet-rich plasma (PRP), are being explored as potential treatments to enhance sexual function in affected women. Methods This original study involved 23 women aged 37 to 72, all diagnosed with varying degrees of FSD (mild, moderate, severe). The participants underwent a pre-treatment evaluation using a custom-designed Likert scale (Female Sexual Health Questionnaire) designed by the authors to evaluate the symptoms of the patients. The treatment involved a single session combining hybrid carbon dioxide 10600 nm and 1540 nm laser therapy with PRP applied to the genital area. One month post-treatment, participants were reassessed using the same questionnaire. Results Of the 23 patients studied, 65.2% (15 patients) exhibited hypoactive sexual desire, and 73.33% of them (11 out of 15) demonstrated improvement post-treatment (P = 0.00048). Overall sexual satisfaction increased by 28.2% (P = 0.0032), and lubrication improved in 54.5% of patients (P = 0.0027). Significant reductions in dyspareunia were observed, with 80% of patients experiencing pain relief (P = 0.0035). Patients with moderate dysfunction showed the highest response, with 100% (6 out of 6) demonstrating improvement across domains (P = 0.0009). Postmenopausal women experienced a 30.9% improvement in sexual function (P = 0.007), while premenopausal women exhibited a 7.5% improvement (P = 0.04). Statistically significant changes were also noted in the frequency of orgasm (P = 0.0058) and genital sensitivity in patients with moderate dysfunction. Conclusion Our data indicated significant improvements in FSD, particularly in moderate to severe dysfunction, with positive changes in key aspects of sexual function such as lubrication, desire, and ease of orgasm. However, the limited number of participants and short follow-up in this pilot study highlight the need for further investigation into hybrid CO2/1540 nm laser therapy combined with PRP as a therapeutic option for female sexual dysfunction.