Abstract
Early detection of widespread undiagnosed sleep apnea is crucial for preventing its severe health complications. However, large-scale diagnosis faces inaccessible monitoring and trust barriers in automated analysis, particularly due to the absence of transparent artificial intelligence frameworks capable of monitoring adaptation. Here, we develop Apnea Interact Xplainer, a transparent system enabling sleep apnea diagnosis through flexible channel analysis across clinical and home settings. Analyzing 15,807 polysomnography recordings from seven independent multi-ethnic cohorts, our system achieves accuracies of 0.738-0.810 for four-level severity classification, with 99.8% accuracy within one severity grade and R-squared of 0.92-0.96 for apnea-hypopnea index prediction on external test cohorts. The system provides multi-level expert-logic interpretable visualization of respiratory patterns enabling transparent collaborative decision-making. Notably, it achieves a sensitivity of 0.970 for early sleep apnea detection using only oximetry signals, while providing nightly risk assessment and intelligent monitoring reports. This study establishes a paradigm shift in advancing early and cost-effective sleep apnea diagnosis through transparent artificial intelligence.