Hormone receptor status score is negatively correlated with adverse pathological features and serves as an independent prognostic factor in endometrial carcinoma

激素受体状态评分与不良病理特征呈负相关,并且是子宫内膜癌的独立预后因素。

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Abstract

OBJECTIVE: To investigate the effect of estrogen and progesterone receptor status score on the prognosis of endometrial cancer (EC) patients. METHODS: We chose 187 endometrial cancer patients hospitalized in The Affiliated Hospital of Southwest Medical University between March 2021 and March 2023. The histologic score (H score) and the Allred score were used to evaluate and analyze their correlation with clinical pathological parameters and prognosis. RESULTS: The hormone receptor status score was negatively correlated with lymph node metastasis (LNMs), differentiation degree, depth of invasion (DOI), and the clinical stage (P<0.05). The hormone receptor status score was significantly higher in the survival group compared to that in the dead group (P<0.05). According to multivariate logistic regression analysis, the hormone receptor status score was identified as an independent protective factor for endometrial cancer patient prognosis (P<0.05). CONCLUSION: The hormone receptor status score has a definite correlation with LNMs, DOI, differentiation degree, and clinical stage in EC patients, and is related to prognosis.

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