Taraxacum officinale Seed Extract Inhibits HeLa Cell Migration at Sub-cytotoxic Concentrations

蒲公英种子提取物在亚细胞毒性浓度下抑制HeLa细胞迁移

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Abstract

Dandelion seed extract exhibits potent anticancer activity in HeLa cells. HeLa viability decreased with increasing doses of DSE from 0 to 0.8 mg/mL, while HDF viability was not affected under similar conditions. DSE reduced HeLa cells' migration speed between 0-0.050 mg/mL, while no significant effect was observed in HDF cells over the same range. Both cell lines exhibited a significant decrease in cell migration speed at 0.1 mg/mL. This data suggests that DSE treatment inhibits cell migration before it significantly reduces cell viability. It points to a specific anti-migratory effect independent of viability loss.

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