Rapid dopaminergic signatures in movement: Reach vigor reflects reward prediction error and learned expectation

运动中多巴胺能的快速变化:伸展力度反映了奖励预测误差和习得的预期

阅读:1

Abstract

Movements become more vigorous when rewards are expected, suggesting that motivational signals influence motor control. Dopaminergic neurons, known to encode reward expectation and prediction error, are prime candidates for linking value and vigor. Here, we show that human reach vigor dynamically tracks canonical dopaminergic learning signals not only at movement onset but also during ongoing motion. Using a reaching task with probabilistic rewards (0, 33, 66, and 100%), we observed that peak velocity scaled with expected value. Crucially, following feedback, reach velocity was transiently invigorated or enervated in proportion to the sign and magnitude of the reward prediction error. Trial-by-trial changes in kinematics reflected value updating, consistent with dopaminergic phasic learning signals. These results demonstrate that movement vigor is modulated by reward-learning signals on rapid timescales, revealing a real-time behavioral readout of motivational computation in the brain.

特别声明

1、本页面内容包含部分的内容是基于公开信息的合理引用;引用内容仅为补充信息,不代表本站立场。

2、若认为本页面引用内容涉及侵权,请及时与本站联系,我们将第一时间处理。

3、其他媒体/个人如需使用本页面原创内容,需注明“来源:[生知库]”并获得授权;使用引用内容的,需自行联系原作者获得许可。

4、投稿及合作请联系:info@biocloudy.com。